Abstract:

The choice of TCP over UDP (or vice versa) might not always be obvious. In a sense, replacing TCP with UDP is trading off reliability for interactivity.

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The most critical factor in selection of TCP over UDP or vice versa is usually related to acceptable delays

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You can still use HLAPI despite its shortcomings

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If you're using one of the engines above (and not your own one), and your game requires Client-Driven Development Flow, you may want to start with a single-player Unity 5, or with a single-player UE4.

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Modifying generated code usually qualifies as a Really Bad Idea

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How much can be gained by each of such specialized encodings – still depends on the game, but if you can try-and-test a dozen of different encodings within a few hours – it will usually allow you to learn quite a few things about your traffic (and to optimize things both visually and traffic-wise too).

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In other words, you can write your code 'as if' all-your-code-within-the-same-FSM executed within the same thread

Another Quote:

As soon as we have these two parts of processing – we can say that our Server-to-Server communication is tolerant to all kinds of transient inter-server disconnects